E. Adamek, W. Baran, R. Adamczyk
Medical University of Silesia in Katowice, Katowice, PL

AN ABIOTIC HYDROLYSIS OF THE SELECTED ANTIBIOTICS USED IN VETERINARY; A CHRONIC TOXICITY THE PRODUCTS


In the hydrosphere, chemical substances are transformed by abiotic or biotic mechanisms in chemical and biological processes. The formed products and/or intermediates as well their effect on the environment may be different. One of these processes is an abiotic hydrolysis. The aim of the study was to determine the kinetics of hydrolysis of three selected antibiotics used in veterinary, i.e. ampicillin, doxycycline and tylosin. Additionally, the chronic toxicity of solutions containing the hydrolysis products of these antibiotics was assessed. Hydrolysis reactions were conducted under aseptic conditions at the natural pH (without correction) at temp. 30oC for 144 days. At this time, the changes in drugs concentration, the changes in organic carbon content and the changes in cumulative chronic toxicity of antibiotics solutions were assessed. During the experiment, the hydrolysis rate constants for ampicillin, doxycycline and tylosin were 0.0674, 0.0075 and 0.0033 days-1, respectively. A decrease in the organic carbon content in the studied samples was not observed but the cumulative chronic toxicity decreased.

Keywords: antibiotics, environment, hydrolysis, chronic toxicity.